Fig. 10.
Bronchial hyperreactivity. The C57Bl/6 mice were treated with Lacticaseibacillus rhamnosus (109 CFU of Lr in 300 µL of PBS, orogastric by gavage) for 14 days or one day, before E. coli LPS instillation (0.5 mg/Kg, intranasal). The mice were euthanized 24 h after the LPS. The bronchial hyperreactivity were processed according to Materials and Methods. Measurement of BSM contraction forces were performed by varying the concentration of MCh-levels from 10‒10 to 10‒3M. The results are expressed as mean ± SEM. Statistically significant differences p < 0.05 comparing the groups (control, Lr/1d+LPS, Lr/14d+LPS) with the LPS group are represented by the symbols in the figure.