Figure 3.
Disruption of community structure and composition post-stroke
(A) Representative cresyl violet stained sections, 3 days after tMCAO. Scale bar: 4 mm
(B) Alpha diversity measurements between stroke and sham mice showing richness (left), Shannon effective (center), and Faith’s phylogenetic diversity (right). Individual points dots represent a single mouse. Error bars represent the median +/− 1.5 multiplied by the IQR. Outliers are highlighted by an empty square
(C) Non-metric multidimensional scaling plot of Generalized UniFrac distance colored by group (Adonis PERMANOVA R2 = 0.12, p-value = 0.018)
(D) Family-level relative abundance in sham and stroke mice. Low abundant families were grouped with each other
(E) Significant differentially abundant taxa between stroke and sham mice, identified by ANCOM-BC (corrected p-value <0.05). Log2 Fold-change between conditions is shown on the x axis