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. 2022 Feb 25;119(11):e2116730119. doi: 10.1073/pnas.2116730119

Fig. 4.

Fig. 4.

Differential association of IFNs with seroconversion. (A–F) Scatter plots comparing relationships between plasma proteins measured by MS proteomics and IFNs in COVID-19 patients. Points are colored by density; blue lines represent linear model fit with 95% confidence intervals in gray. (G) Heatmap representing correlations between IFNs and plasma levels of Igs measured by MS proteomics (Upper), or antibody reactivity against SARS-CoV-2 measured by immunoassays (Lower). Values displayed are Spearman correlation scores (rho); asterisks indicate significant correlations (10% FDR); columns and rows are grouped by hierarchical clustering. (H) Scatter plots comparing relationships between plasma antibody reactivity against SARS-CoV-2 S1 RBD region and IFNA2/B1 in COVID-19 patients. Points are colored by density; blue lines represent linear model fit with 95% confidence intervals in gray. See also SI Appendix, Figs. S5 and S6. n.s., not significant.