Fig. 6.

Differential metabolic signatures associated with IFNs. (A) Heatmap representing correlations between IFNs and plasma metabolites. Values displayed are Spearman correlation scores (rho); asterisks indicate significant correlations (10% FDR); columns and rows are grouped by hierarchical clustering. (B–E) Scatter plots comparing relationships between select metabolites and IFNs in COVID-19 patients. Points are colored by density; blue lines represent linear model fit with 95% confidence intervals in gray. See also SI Appendix, Figs. S9 and S10. n.s., not significant.