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. 2022 Mar 4;13:841470. doi: 10.3389/fimmu.2022.841470

Figure 2.

Figure 2

Survival analyses and ratio establishment. (A) Impact of individual allele HED on overall (OS) and disease-free (DFS) survival for both recipients and donors. Adjusted hazard ratio (HR) were calculated using a multivariate cox model controlling for disease status, HCT number, conditioning, use of total body irradiation, HLA matching, and graft source. (B) Evaluation of the impact on DFS of the four established scores in the training (left) and testing (right) cohorts. Adjusted HR were calculated using a multivariate cox model controlling for disease status, HCT number, conditioning, use of total body irradiation, HLA matching, and graft source. FDR-adjusted p-values significance is represented (*: < 0.05, **: < 0.01, ***: < 0.001). (C) Kaplan Meier curves of DFS (left) and OS (right) according to the median class I/class II HED ratio (score 1) in the testing cohort. (D) Final multivariate cox models of DFS (left) and OS (right) according to the median class I/class II HED ratio (score 1), disease status, HCT number, conditioning, HLA matching, and graft source in the testing cohort. A non-adjusted p-value cutoff of 0.01 was considered for significancy in the final multivariate model. DFS, disease free survival; HED, HLA evolutionary divergence; CI, confidence interval; HCT, hematopoietic cell transplantation; HLA, Human leukocyte antigens; HR, hazard ratio; OS, overall survival.