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. 2022 Feb 19;298(4):101749. doi: 10.1016/j.jbc.2022.101749

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Relationships between ABA3 and STR18 in sulfur trafficking in cytosol. ABA3 catalyzes the desulfuration of cysteine, leading to the persulfidation of the catalytic cysteine of the CD domain and the concomitant release of alanine (1). Then, the persulfidation of STR18 might occur either via the CD domain (2A) or the MOSC domain (2B) of ABA3. In the next step, STR18 catalyzes a transpersulfidation reaction leading to persulfidation of the target protein (3). This pathway might be independent of the involvement of ABA3 in the sulfuration of Moco-containing proteins (4). CD, cysteine desulfurase; Moco, molybdenum cofactor; STR18, sulfurtransferase 18.