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. 2022 Mar 4;13:841918. doi: 10.3389/fphar.2022.841918

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Copyright © 2022 Zhou, Wang, Ji, Zhang, Ma, Ma, Ma, Jiang, Du, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in gene and protein expression. Changes in related genes of HCT116 after cocultivation with F. nucleatum (Fn, MOI = 100, 2 h) and treatments with IPM711 and IPM712 at the concentration of IC₅₀ (A). Changes in E-cadherin and β-catenin proteins of HCT116 after cocultivation with F. nucleatum (MOI = 100, 2 h) and treatments with IPM711 and IPM712 (IC₅₀) (B). Statistical analysis, *p < 0.05, **p < 0.01, ***p < 0.001 compared with control group (C). Characterization of migratory capacity of HCT116 cells after treatment with RPMI-1640, F. nucleatum, F. nucleatum and IPM711, and F. nucleatum and IPM712 (D). Statistical analysis, *p < 0.05 compared with control group (E).