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. 2022 Mar 4;10:807139. doi: 10.3389/fbioe.2022.807139

TABLE 5.

Threshold method results for TOS and SWS compared with VS for data sets.

Combined set Training set Additional set
+ve VS cycles 158 75 83
−ve VS cycles 47 18 29
Total cycles 205 93 112
Participants 80 60 55
Thresholds ±1 day ±3 days ±1 day ±3 days ±1 day ±3 days
Method TOS SWS TOS SWS TOS SWS TOS SWS TOS SWS TOS SWS
TP 86 88 119 140 43 47 55 71 43 41 64 69
FP 53 63 20 11 23 26 11 2 30 37 9 9
TN 43 45 43 45 16 18 16 18 27 27 27 27
FN 23 9 23 9 11 2 11 2 12 7 12 7
Total cycles 205 205 205 205 93 93 93 93 112 112 112 112
Sensitivity 79% 91% 84% 94% 80% 96% 83% 97% 78% 85% 84% 91%
Specificity 45% 42% 68% 80% 41% 41% 59% 90% 47% 42% 75% 75%
PPV 62% 58% 86% 93% 65% 64% 83% 97% 59% 53% 88% 88%
NPV 65% 83% 65% 83% 59% 90% 59% 90% 69% 79% 69% 79%
Accuracy 62.9% 64.9% 79.0% 90.2% 63.4% 69.9% 76.3% 95.7% 62.5% 60.7% 81.3% 85.7%
Upper CI 95% 69.6% 71.4% 84.4% 93.9% 73.2% 79.0% 84.5% 98.8% 71.5% 69.8% 88.0% 91.6%
Lower CI 95% 55.9% 57.9% 72.8% 85.3% 52.8% 59.5% 66.4% 89.4% 52.9% 51.0% 72.8% 77.8%
F score 0.69 0.71 0.85 0.93 0.72 0.77 0.83 0.97 0.67 0.65 0.86 0.90
Upper CI 95% 0.77 0.79 0.90 0.97 0.83 0.87 0.91 1.00 0.78 0.77 0.93 0.95
Lower CI 95% 0.60 0.62 0.78 0.88 0.59 0.65 0.72 0.90 0.54 0.52 0.76 0.81

Note. A single participant was able to take part in both the Training Set and the Additional Set; hence, each participant was able to have one or more cycles, which contributed to both groups, and the total number of participants added together for those two groups in the table above is therefore more than the 80 total participants with positive and negative cycles.

TP, true positive; FP, false positive; TN, true negative; FN, false negative; PPV, positive predictive value; NPV, negative predictive value.