Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 4;13:800810. doi: 10.3389/fphar.2022.800810

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Liu, Zhang, Wang, Wang, Qiu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanisms of SUMOylation and deSUMOylation by key mediators in renal fibrosis and therapeutic targets of natural products against renal fibrosis via SUMOylation. Mechanisms of SUMOylation and deSUMOylation by key mediators in renal fibrosis are including podocyte apoptosis, and OAT3-mediated transfer channels. As one of component of the slit diaphragm, nephrin is SUMOylated by SUMO1 and SUMO2/3. CD2AP promotes the expression of nephrin by inhibiting the SUMOylation of CIN85. Drp1 is SUMOylated by SUMO1 and SUMO2/3. OAT3 is SUMOylated by SUMO2/3. SNEP3 deSUMOylates Drp1, and SNEP2 deSUMOylates OAT3. Ginkgolic acid inhibits the expression of nephrin by downregulating SUMO1 and SUMO2/3.