TABLE 1.

The SUMOylation of transcription factors and key mediators in renal fibrosis.

Model	SUMO proteins or enzymes	Target genes	References
Modulating transcription factors
High glucose induced renal mesangial cells	SUMO2/3	Smad4	Zhou et al. (2014)
Senp1(−/−) mice	SENP1	HIF-1α	Xu et al. (2010)
Co-culture models of glomerular endothelial cells with podocytes	SENP1	HIF-1α	Wang et al. (2015)
Puromycin aminonucleoside-induced podocyte	SENP1	p53	Wang et al. (2014)
Renal mesangial cells	SUMO1	p53	Wu et al. (2021)
Rat kidney proximal tubular cells	SUMO2/3	p53	Guo et al. (2015)
HEK 293T, HCT- 116 p53−/− and all RKO cells	SUMO1	p53	Wagner et al. (2015)
High glucose stimulated rat glomerular mesangial cells	SUMO1 and SUMO2/3	NF-κB p65	Huang et al. (2013)
High glucose stimulated rat glomerular mesangial cells	E3	NF-κB p65	Huang et al. (2017)
Lipopolysaccharide (LPS)-induced human renal proximal tubular cells	E3	PPARγ	Lu et al. (2013)
diabetic GK rats	SUMO4	NF-κB p65	Chen et al. (2014)
C57BL/6 mice, HEK293T, MEF and RAW264.7 cells	SUMO2/3	NEMO/IKKγ	Liu et al. (2013)
C57BL/6 mice, HEK293T, MEF and RAW264.7 cells	SENP6	NEMO	Liu et al. (2013)
Modulating key mediators
C57/Bl6 mice and podocytes HEK-293T	SUMO1 and SUMO2/3	Nephrin	Tossidou et al. (2014)
Podocytes	SUMO1 and SUMO2/3	CIN85	Tossidou et al. (2012)
HEK293 and HeLa cells	SENP3	Drp1	Guo et al. (2017)
COS-7 fibroblasts	SENP2	OAT3	Wang and You, (2019)
COS-7 fibroblasts	SUMO2/3	OAT3	Wang et al. (2019)