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. 2022 Mar 4;9:841814. doi: 10.3389/fmolb.2022.841814

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Copyright © 2022 Oliveri.

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Chemical structure of PNap and the proposed mechanism for the release of Nap upon the action of H₂O₂ and a spontaneous 1,6 benzyl elimination. Then, Nap is alkylated by GSH and acts as a Cu ionophore. The arrows highlight the processes, which occur intracellularly (GSH depletion and Cu accumulation).