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. Author manuscript; available in PMC: 2022 Mar 18.
Published in final edited form as: Neurosci Biobehav Rev. 2021 Sep 28;131:847–864. doi: 10.1016/j.neubiorev.2021.09.050

Figure 4. Neurobiology of incubation of food craving.

Figure 4.

Graphic overview of pharmacological manipulations and molecular adaptations underling the attenuation (blue) (Grimm et al., 2007; Uejima et al., 2007; Grimm et al., 2011; McCue et al., 2019) or the exacerbation (red) (Grimm et al, 2002; Grimm et al., 2003; Glueck et al, 2017; Grimm et al., 2006; Cuonotte et al., 2014; Grimm et al., 2016; Grimm et al., 2018) of incubation of food craving. Green indicates the pharmacological manipulations; orange indicate the molecular mechanisms. Abbreviations: NAc, nucleus accumbens, CeA, central amygdala; NMUR2, neuromedin U receptor 2; PVN, paraventricular nucleus of hypothalamus; VTA, ventral tegmental area; OFC, orbitofrontal cortex; DMS, dorsomedial striatum; DLS, dorsolateral striatum; mPFC, medial prefrontal cortex; ACC, anterior cingulate cortex; SMA, somatosensorial cortex.