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. 2022 Mar 4;13:756034. doi: 10.3389/fimmu.2022.756034

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Copyright © 2022 Hsu, Wang, Syahirah, Liu, Li, Zhang, Wang, Cao, Tian, Matosevic, Staiger, Wan and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-Seq reveals the direction of rorα possible downstream genes in neutrophil migration. (A) Volcano blot of DEGs with significant expression changes in rorα DN neutrophils. Cyan: down-regulated differentially expressed genes (DEGs); Magenta: up-regulated DEGs. (B) Significant gene function enrichment of human homologs of genes in the down-regulated DEGs. The heat map indicates the log2 fold change of the selected DEGs. The relevance of individual DEGs in each pathway is indicated with purple. (C) Venn diagram showing human homologs of genes in the down-regulated DEGs overlapping with putative RORα target genes in THP-1 or HUVEC cells. (D) Transcript level validation of downregulated genes in neutrophils sorted from rorα DN line zebrafish. Results from three independent experiments are normalized to rpl32 and presented as mean ± s.d., students’ t-test.