Table 2. Diagnostic Accuracy of DL Model Performance in Identifying Primary Open-Angle Glaucoma by the Ocular Hypertensive Treatment Study (OHTS) Endpoint Committee and Optic Disc and Visual Field Reading Centers.
| POAG detection modality | POAG, No. | AUROC (95% CI) | Specificity | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Participants | Eyes | Visits | All eyes | Eyes with early glaucoma (VF MD ≥−6 dB) | 80% | 85% | 90% | 95% | |||||
| Sensitivity | Precision | Sensitivity | Precision | Sensitivity | Precision | Sensitivity | Precision | ||||||
| OHTS Endpoint Committee | |||||||||||||
| Optic disc and/or visual field changes | 52 | 71 | 352 | 0.88 (0.82-0.92) | 0.86 (0.79-0.91) | 0.81 | 0.21 | 0.77 | 0.26 | 0.69 | 0.32 | 0.56 | 0.43 |
| Optic disc changes | 41 | 56 | 262 | 0.91 (0.88-0.94) | 0.90 (0.87-0.94) | 0.86 | 0.17 | 0.81 | 0.21 | 0.73 | 0.26 | 0.56 | 0.35 |
| Visual field changes | 35 | 41 | 195 | 0.86 (0.76-0.93) | 0.83 (0.70-0.91) | 0.80 | 0.14 | 0.76 | 0.17 | 0.69 | 0.22 | 0.55 | 0.31 |
| Reading center | |||||||||||||
| Optic Disc Reading Center | 60 | 77 | 318 | 0.89 (0.85-0.92) | 0.87 (0.83-0.91) | 0.83 | 0.20 | 0.77 | 0.23 | 0.71 | 0.30 | 0.56 | 0.40 |
| Visual Field Reading Center | 61 | 78 | 242 | 0.83 (0.76-0.88) | 0.80 (0.72-0.86) | 0.69 | 0.15 | 0.64 | 0.18 | 0.58 | 0.22 | 0.48 | 0.32 |
Abbreviations: AUROC, area under the receiver operating characteristic curve; MD, mean deviation; POAG, primary open-angle glaucoma; VF, visual field.