Supplementary material 2. Summary of recommendations on lifestyle changes and Pca.

Diet Consumption of cruciferous vegetables (broccoli, cauliflower) Increased consumption of tomato and its preparations Mediterranean diet pattern or DASH diet* Reduce consumption of simple carbohydrates and saturated fats Consumption of green tea and coffee (3-5 cups per day) Reduce consumption of red meats and processed products

Exercise At least 150 minutes/week Long-term physical activity Pelvic floor exercise for symptoms of urinary incontinence in post-prostatectomy patients Neoadjuvant or adjuvant exercise in patients on chemotherapy or radiation therapy, and in patients in ADT**

Mental Health and Work Screening for depressive, anxious, psychological stress symptoms Include psychosocial support within standard management Provide the opportunity for psychotherapy or peer support Comprehensive approach to the couple Avoid night shift jobs Providing multidisciplinary care to promote return to work

Multimodal treatment Close monitoring of all patients undergoing surgery, hormone therapy and radiation therapy with joint monitoring of their lifestyle and risk factors Similar recommendations in patients with castration-resistant metastatic PCa***