Skip to main content
. 2008 Apr 23;2008(2):CD007031. doi: 10.1002/14651858.CD007031

Comparison 1. Ciclesonide versus Beclomethasone or Budesonide (dose ratio 1:1).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Change from baseline in FEV1 4 1322 L (Random, 95% CI) 0.03 [‐0.06, 0.11]
1.1 Children 0 0 L (Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Adults 4 1322 L (Random, 95% CI) 0.03 [‐0.06, 0.11]
2 Change from baseline in FVC 3 970 L (Fixed, 95% CI) 0.06 [0.01, 0.11]
2.1 Children 1 399 L (Fixed, 95% CI) 0.11 [0.00, 0.22]
2.2 Adults 2 571 L (Fixed, 95% CI) 0.05 [‐0.00, 0.10]
3 Change from baseline in clinic PEF (L/min) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.1 Children 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 Adults 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Change from baseline in am PEF 4 1329 L/min (Fixed, 95% CI) 5.37 [0.12, 10.61]
4.1 Children 0 0 L/min (Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Adults 4 1329 L/min (Fixed, 95% CI) 5.37 [0.12, 10.61]
5 Change from baseline in pm PEF 2 758 L/min (Fixed, 95% CI) 3.95 [‐2.89, 10.80]
5.1 Children 0 0 L/min (Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 Adults 2 758 L/min (Fixed, 95% CI) 3.95 [‐2.89, 10.80]
6 Change in asthma symptom score 1   Symptom score units (Random, 95% CI) Totals not selected
6.1 Children 0   Symptom score units (Random, 95% CI) 0.0 [0.0, 0.0]
6.2 Adults 1   Symptom score units (Random, 95% CI) 0.0 [0.0, 0.0]
7 Withdrawals (total) 2 771 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.47, 1.19]
7.1 Children 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.2 Adults 2 771 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.47, 1.19]
8 Withdrawals (lack of efficacy) 3 1130 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.88, 2.01]
8.1 Children 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Adults 3 1130 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.88, 2.01]
9 Adverse events 3 1131 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.85, 1.15]
9.1 Children 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.2 Adults 3 1131 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.85, 1.15]
10 Candidiasis 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
11 Pharyngitis 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
13 Exacerbations of asthma 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
13.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
13.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Sore throat 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
15 Voice alteration 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
16 Changes in cortisol levels (urinary) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
16.1 Children 0   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16.2 Adults 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
17 Asthma (not otherwsie specified) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
17.1 Children 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
17.2 Adults 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
18 Upper respiratory tract infection 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
18.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
18.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
19 Headache 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
19.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
19.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
21 Rhinitis 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
21.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 Withdrawals (adverse events) 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
22.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
23 Cough 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
23.1 Children 0   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
23.2 Adults 1   Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
25 Data not suitable for meta‐analysis (medians)     Other data No numeric data
25.1 Symptoms     Other data No numeric data
25.2 Rescue medication use     Other data No numeric data