Comparison 5. Change in FEV1: Intention to treat versus per protocol analysis populations.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Ciclesonide versus Beclomethasone or Budesonide (dose ratio 1:1)	4		L (Fixed, 95% CI)	Subtotals only
1.1 ITT	4	1322	L (Fixed, 95% CI)	0.03 [‐0.01, 0.07]
1.2 PP	2	618	L (Fixed, 95% CI)	0.01 [‐0.05, 0.06]
2 Ciclesonide versus Beclomethasone or Budesonide (dose ratio 1:2)	7		L (Fixed, 95% CI)	Subtotals only
2.1 ITT	5	1633	L (Fixed, 95% CI)	‐0.02 [‐0.05, 0.00]
2.2 PP	6	1574	L (Fixed, 95% CI)	‐0.03 [‐0.06, 0.00]
3 Ciclesonide versus Fluticasone (dose ratio 1:1)	5		L (Fixed, 95% CI)	Subtotals only
3.1 ITT	5	2599	L (Fixed, 95% CI)	‐0.02 [‐0.04, 0.01]
3.2 PP	5	2178	L (Fixed, 95% CI)	‐0.01 [‐0.04, 0.02]
4 Ciclesonide versus Fluticasone (dose ratio 1:2)	2		L (Fixed, 95% CI)	Subtotals only
4.1 ITT	1	537	L (Fixed, 95% CI)	‐0.03 [‐0.11, 0.06]
4.2 PP	2	888	L (Fixed, 95% CI)	‐0.05 [‐0.11, 0.01]