. 2014 Jul 16;2014(7):CD009878. doi: 10.1002/14651858.CD009878.pub2

Comparison 1. Inhaled corticosteroids dose‐response effect.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Growth velocity (cm/y) by stadiometry from 0‐12 months	4	728	Mean Difference (IV, Fixed, 95% CI)	0.20 [0.02, 0.39]
2 Subgroup analysis on the ICS molecules: growth velocity by stadiometry from 0‐12 months	4	728	Mean Difference (IV, Fixed, 95% CI)	0.20 [0.02, 0.39]
2.1 Mometasone	2	139	Mean Difference (IV, Fixed, 95% CI)	0.58 [0.02, 1.13]
2.2 Ciclesonide	1	408	Mean Difference (IV, Fixed, 95% CI)	0.13 [‐0.09, 0.35]
2.3 Fluticasone	1	181	Mean Difference (IV, Fixed, 95% CI)	0.24 [‐0.16, 0.64]
3 Growth velocity (cm/y) by stadiometry from 0‐3 months	6	1114	Mean Difference (IV, Fixed, 95% CI)	‐0.12 [‐0.51, 0.27]
4 Growth velocity (cm/y) by stadiometry from 0‐6 months	2	60	Mean Difference (IV, Fixed, 95% CI)	‐0.33 [‐2.40, 1.75]
5 Growth velocity (cm/y) by stadiometry from 3‐6 months	2	58	Mean Difference (IV, Fixed, 95% CI)	‐0.13 [‐3.35, 3.10]
6 Change in growth velocity (cm/y) by stadiometry from 0‐12 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7 Change in height (cm) by stadiometry from 0‐3 months	9	944	Mean Difference (IV, Fixed, 95% CI)	‐0.15 [‐0.28, ‐0.02]
8 Change in height (cm) by stadiometry from 0‐6 months	3	211	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.27, 0.33]
9 Change in height (cm) by stadiometry from 3‐6 months	2	58	Mean Difference (IV, Fixed, 95% CI)	‐0.01 [‐0.74, 0.71]
10 Change in height (cm) by stadiometry from 0‐12 months	4	548	Mean Difference (IV, Fixed, 95% CI)	0.25 [‐0.04, 0.54]
11 Change in SD scores (height) from 0‐12 months	3	328	Mean Difference (IV, Random, 95% CI)	0.08 [‐0.03, 0.20]
12 Change in weight (kg) from 0‐3 months	5	449	Mean Difference (IV, Random, 95% CI)	0.27 [‐0.13, 0.66]
13 Change in weight (kg) from 0‐6 months	2	346	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.24, 0.24]
14 Change in weight (kg) from 0‐12 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
15 Change in BMI (kg/m²) from 0‐6 months	2	278	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.22, 0.33]
16 Change in BMI (kg/m²) from 0‐12 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
17 Change in skeletal maturation (years) from 0‐12 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected