Chen 2001.

Methods	Randomised, single‐blind, placebo‐controlled, parallel‐group study; 1 centre
Participants	SYMPTOMATIC PARTICIPANTS RANDOMLY ASSIGNED: N = 20 INTERVENTION: ICS: (beclomethasone dipropionate 200 μg/d): 10 CONTROL: ICS (beclomethasone dipropionate 400 μg/d): 10 WITHDRAWALS: no withdrawals AGE: mean (years) (range): INTERVENTION: ICS (beclomethasone dipropionate 200 μg/d): average 7 years CONTROL: ICS (beclomethasone dipropionate 400 μg/d): average 9 years GENDER: N (male %): not reported ASTHMA SEVERITY: mild asthma ASTHMA DURATION: not reported MEAN (± SD) β2‐AGONIST USE (puffs/d): not reported DOSE OF ICS AT STUDY ENTRY AND AT RUN‐IN: not reported ATOPY (% of participants): not reported ELIGIBILITY CRITERIA Children with mild asthma, diagnosed according to the Chinese Medical Society Respiratory Diseases Branch Asthma Group Not using any corticosteroid in past 6 months before inclusion in the study EXCLUSION CRITERIA Not reported
Interventions	PROTOCOL DURATION Run‐in = 12 weeks Intervention = 52 weeks DEVICE: not reported (in translation of the study) DOSE OF ICS INTERVENTION: beclomethasone dipropionate 200 μg/d CONTROL: beclomethasone dipropionate 400 μg/d CRITERIA FOR WITHDRAWAL FROM STUDY: reported
Outcomes	ANALYSIS: not reported (in translation of the study) OUTCOMES GROWTH MEASUREMENT TECHNIQUE: not reported (in translation of the study) PULMONARY FUNCTION TESTS Bronchial inhalation of histamine provocation test FUNCTIONAL STATUS Children’s height BIOMARKERS HPAA function BMD, osteocalcin, serum calcium concentration, serum phosphorus concentration, blood alkaline phosphatase ADVERSE EVENTS: not reported WITHDRAWALS: no withdrawals
Notes	PUBLICATION: full paper (2001) FUNDING: not reported CONFIRMATION OF METHODOLOGY: not received Study author could not be contacted
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Using a random number table: “The patients were allocated by random number table and stratified by moderate and severe grades”
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No blinding or incomplete blinding; single‐blind
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No blinding or incomplete blinding; single‐blind
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Reasons for missing outcome data unlikely to be related to true outcomes
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists