Fig. 2.

HUCMSCs-exo or exosomal miR-140-3p attenuates joint injury of RA rats and reduced miR-140-3p reverses the effect of HUCMSCs-exo on joint injury of RA rats. A Pathological changes in rat feet; B Serum contents of TNF-α and IL-1β in rats; C Serum activity of SOD in rats; D Serum content of MDA in rats; E Pathology of rat ankle joints was observed through HE staining; F RA score of rats after HE staining; G Masson staining was used to observe the fibrosis in tibial articular cartilage of rats; H Fibrosis was quantified based on Masson staining; n = 5; *P < 0.05 vs the sham group, ^P < 0.05 vs the CIA group, ^#P < 0.05 vs the mimic-NC-exo group, ^&P < 0.05 vs the inhibitor-NC-exo group; the data were expressed as mean ± standard deviation, ANOVA was used for comparisons among multiple groups and Tukey’s post hoc test was used for pairwise comparisons after ANOVA