Table 5.
The association between three NPAR groups and 180-day all-cause mortality in subgroup analysis
| N | NPAR < 21.58 (reference) |
21.58 ≤ NPAR < 26.77 HR (95% CIs) |
NPAR ≥ 26.77 HR (95% CIs) |
p for interaction | |
|---|---|---|---|---|---|
| AF | 0.4736 | ||||
| No | 551 | 1.0 | 1.42 (0.90, 2.23) | 2.80 (1.85, 4.26) | |
| Yes | 247 | 1.0 | 1.55 (0.86, 2.81) | 2.19 (1.26, 3.82) | |
| CHF | 0.1939 | ||||
| No | 422 | 1.0 | 1.18 (0.68, 2.07) | 2.89 (1.79, 4.67) | |
| Yes | 376 | 1.0 | 1.60 (0.99, 2.59) | 2.30 (1.45, 3.65) | |
| CKD | 0.5369 | ||||
| No | 690 | 1.0 | 1.54 (1.04, 2.27) | 2.53 (1.76, 3.64) | |
| Yes | 108 | 1.0 | 1.21 (0.47, 3.13) | 3.12 (1.35, 7.22) | |
| COPD | 0.9520 | ||||
| No | 784 | 1.0 | 1.50 (1.04, 2.16) | 2.62 (1.87, 3.67) | |
| Yes | 14 | 1.0 | 2.42 (0.15, 39.05) | 3.37 (0.40, 28.33) | |
| CAD | 0.8694 | ||||
| No | 253 | 1.0 | 1.72 (0.92, 3.23) | 2.54 (1.48, 4.36) | |
| Yes | 545 | 1.0 | 1.45 (0.94, 2.26) | 2.49 (1.61, 3.83) | |
| Hypertension | 0.3855 | ||||
| No | 453 | 1.0 | 1.19 (0.74, 1.91) | 2.34 (1.54, 3.55) | |
| Yes | 345 | 1.0 | 1.95 (1.11, 3.41) | 2.86 (1.64, 4.98) | |
| Diabetes | 0.3603 | ||||
| No | 567 | 1.0 | 1.36 (0.90, 2.06) | 2.32 (1.58, 3.40) | |
| Yes | 231 | 1.0 | 1.99 (0.96, 4.13) | 3.91 (1.99, 7.70) | |
| Prior MI | 0.4050 | ||||
| No | 752 | 1.0 | 1.54 (1.06, 2.25) | 2.84 (2.01, 4.02) | |
| Yes | 46 | 1.0 | 1.09 (0.33, 3.57) | 1.20 (0.35, 4.13) | |
| Stroke | 0.4004 | ||||
| No | 768 | 1.0 | 1.52 (1.05, 2.20) | 2.75 (1.95, 3.88) | |
| Yes | 30 | 1.0 | 0.69 (0.16, 2.91) | 0.92 (0.24, 3.58) | |
| Clopidogre | 0.4357 | ||||
| No | 401 | 1.0 | 1.22 (0.75, 1.99) | 2.37 (1.55, 3.61) | |
| Yes | 397 | 1.0 | 1.97 (1.14, 3.41) | 3.04 (1.77, 5.20) | |
| Aspirin | 0.4040 | ||||
| No | 191 | 1.0 | 0.98 (0.47, 2.05) | 1.93 (1.08, 3.46) | |
| Yes | 607 | 1.0 | 1.73 (1.14, 2.62) | 2.85 (1.90, 4.28) | |
| Metoprolol | 0.8271 | ||||
| No | 236 | 1.0 | 1.30 (0.72, 2.35) | 1.98 (1.17, 3.35) | |
| Yes | 562 | 1.0 | 1.53 (0.97, 2.41) | 2.59 (1.68, 4.00) | |
| ACEI/ARBs | 0.3793 | ||||
| No | 371 | 1.0 | 1.33 (0.83, 2.14) | 2.21 (1.48, 3.31) | |
| Yes | 427 | 1.0 | 1.98 (1.13, 3.47) | 2.19 (1.19, 4.03) | |
| Statin | 0.2013 | ||||
| No | 242 | 1.0 | 1.25 (0.73, 2.15) | 1.68 (1.04, 2.72) | |
| Yes | 556 | 1.0 | 1.67 (1.03, 2.71) | 3.08 (1.94, 4.86) | |
| PTCA/PCI | 0.2614 | ||||
| No | 313 | 1.0 | 1.19 (0.71, 1.99) | 1.73 (1.10, 2.74) | |
| Yes | 485 | 1.0 | 1.69 (1.02, 2.80) | 3.08 (1.89, 5.02) | |
| Gender | 0.7209 | ||||
| Female | 294 | 1.0 | 1.37 (0.76, 2.47) | 2.82 (1.65, 4.83) | |
| Male | 504 | 1.0 | 1.57 (1.00, 2.47) | 2.52 (1.65, 3.86) | |
| Race | 0.5510 | ||||
| White | 518 | 1.0 | 1.43 (0.88, 2.34) | 2.84 (1.85, 4.38) | |
| Black | 46 | 1.0 | 2.63 (0.66, 10.56) | 6.29 (1.49, 26.52) | |
| Other | 234 | 1.0 | 1.26 (0.70, 2.25) | 1.99 (1.14, 3.48) | |
| ALT (U/L) | 0.6194 | ||||
| < 35.81 | 393 | 1.0 | 1.35 (0.80, 2.28) | 2.88 (1.80, 4.64) | |
| ≥ 35.81 | 405 | 1.0 | 1.57 (0.95, 2.58) | 2.41 (1.51, 3.86) | |
| AST (U/L) | 0.8455 | ||||
| < 67.00 | 391 | 1.0 | 1.44 (0.82, 2.52) | 2.84 (1.71, 4.73) | |
| ≥ 67.00 | 407 | 1.0 | 1.45 (0.91, 2.32) 0 | 2.40 (1.55, 3.72) | |
| CK-peak (U/L) | 0.9398 | ||||
| < 823.00 | 397 | 1.0 | 1.46 (0.88, 2.41) | 2.56 (1.64, 4.01) | |
| ≥ 823.00 | 401 | 1.0 | 1.56 (0.93, 2.63) | 2.81 (1.71, 4.62) | |
| CK-MB-peak (U/L) | 0.9731 | ||||
| < 48.00 | 398 | 1.0 | 1.54 (0.91, 2.60) | 2.69 (1.68, 4.30) | |
| ≥ 48.00 | 399 | 1.0 | 1.45 (0.89, 2.38) | 2.66 (1.66, 4.28) | |
| Glucose (mg/dL) | 0.7956 | ||||
| < 148.00 | 395 | 1.0 | 1.53 (0.89, 2.61) | 3.02 (1.85, 4.93) | |
| ≥ 148.00 | 403 | 1.0 | 1.45 (0.89, 2.36) | 2.35 (1.50, 3.70) | |
| PT (s) | 0.2151 | ||||
| < 13.70 | 388 | 1.0 | 1.96 (1.18, 3.27) | 2.82 (1.67, 4.78) | |
| ≥ 13.70 | 410 | 1.0 | 1.03 (0.62, 1.71) | 2.00 (1.28, 3.13) | |
| Hemoglobin (g/dL) | 0.7119 | ||||
| < 12.40 | 394 | 1.0 | 1.20 (0.71, 2.03) | 2.14 (1.34, 3.41) | |
| ≥ 12.40 | 404 | 1.0 | 1.62 (0.98, 2.66) | 2.47 (1.47, 4.15) | |
| RDW (%) | 0.4510 | ||||
| < 13.80 | 394 | 1.0 | 1.37 (0.77, 2.42) | 2.84 (1.65, 4.88) | |
| ≥ 13.80 | 404 | 1.0 | 1.55 (0.97, 2.47) | 2.22 (1.45, 3.39) | |
| Creatinine (mEq/L) | 0.6118 | ||||
| < 1.10 | 303 | 1.0 | 1.76 (0.91, 3.42) | 3.61 (1.91, 6.84) | |
| ≥ 1.10 | 399 | 1.0 | 1.69 (1.05, 2.73) | 2.58 (1.66, 4.02) | |
| BUN (mg/dL) | 0.1007 | ||||
| < 22.00 | 370 | 1.0 | 2.26 (1.21, 4.21) | 3.86 (2.07, 7.20) | |
| ≥ 22.00 | 414 | 1.0 | 1.11 (0.70, 1.75) | 1.84 (1.23, 2.77) | |
| WBC (109/L) | 0.3940 | ||||
| < 12.00 | 383 | 1.0 | 1.38 (0.77, 2.46) | 3.13 (1.85, 5.29) | |
| ≥ 12.00 | 401 | 1.0 | 1.40 (0.85, 2.31) | 2.10 (1.32, 3.35) | |
| Potassium (mmol/L) | 0.5270 | ||||
| < 4.20 | 388 | 1.0 | 1.22 (0.71, 2.08) | 2.43 (1.48, 3.98) | |
| ≥ 4.20 | 410 | 1.0 | 1.83 (1.13, 2.97) | 2.90 (1.85, 4.54) | |
| Sodium (mmol/L) | 0.8463 | ||||
| < 139.00 | 384 | 1.0 | 1.64 (0.97, 2.78) | 2.91 (1.77, 4.78) | |
| ≥ 139.00 | 414 | 1.0 | 1.35 (0.82, 2.24) | 2.46 (1.57, 3.85) | |
| Platelet (109/L) | 0.9992 | ||||
| < 241.00 | 399 | 1.0 | 1.50 (0.90, 2.49) | 2.68 (1.70, 4.21) | |
| ≥ 241.00 | 399 | 1.0 | 1.51 (0.91, 2.52) | 2.62 (1.61, 4.29) | |
| Age (years) | 0.0469 | ||||
| < 70.00 | 394 | 1.0 | 1.26 (0.68, 2.32) | 3.42 (1.99, 5.88) | |
| ≥ 70.00 | 404 | 1.0 | 1.58 (1.01, 2.47) | 2.05 (1.35, 3.12) | |
| Heart rate (beats/minute) | 0.0023 | ||||
| < 101.00 | 385 | 1.0 | 2.61 (1.43, 4.77) | 5.12 (2.89, 9.07) | |
| ≥ 101.00 | 413 | 1.0 | 0.92 (0.59, 1.45) | 1.51 (1.00, 2.28) | |
| Respiratory rate (beats/minute) | 0.8764 | ||||
| < 26.00 | 368 | 1.0 | 1.44 (0.80, 2.58) | 2.83 (1.65, 4.83) | |
| ≥ 26.00 | 430 | 1.0 | 1.54 (0.98, 2.44) | 2.56 (1.67, 3.90) | |
| MBP (mmHg) | 0.4178 | ||||
| < 57.00 | 371 | 1.0 | 1.16 (0.70, 1.92) | 2.23 (1.43, 3.46) | |
| ≥ 57.00 | 427 | 1.0 | 1.87 (1.12, 3.13) | 2.79 (1.68, 4.66) | |
| Weight (kg) | 0.6674 | ||||
| < 78.00 | 392 | 1.0 | 1.76 (1.04, 2.97) | 3.01 (1.84, 4.91) | |
| ≥ 78.00 | 406 | 1.0 | 1.26 (0.76, 2.08) | 2.32 (1.46, 3.69) | |
| ICU LOS (day) | 0.0002 | ||||
| < 3.69 | 399 | 1.0 | 1.28 (0.73, 2.25) | 4.33 (2.66, 7.03) | |
| ≥ 3.69 | 399 | 1.0 | 1.40 (0.87, 2.27) | 1.59 (1.01, 2.52) | |
| SAPS II | 0.0010 | ||||
| < 31.00 | 247 | 1.0 | 8.90 (2.01, 39.44) | 19.22 (4.30, 85.91) | |
| ≥ 31.00, < 45 | 278 | 1.0 | 1.10 (0.58, 2.08) | 1.33 (0.72, 2.45) | |
| ≥ 45 | 273 | 1.0 | 0.96 (0.60, 1.54) | 1.44 (0.95, 2.18) | |
| SOFA | 0.0605 | ||||
| < 3.00 | 247 | 1.0 | 2.17 (0.92, 5.11) | 5.29 (2.19, 12.78) | |
| ≥ 3.00, < 6.00 | 236 | 1.0 | 1.91 (0.96, 3.82) | 1.75 (0.88, 3.50) | |
| ≥ 6.00 | 315 | 1.0 | 0.95 (0.58, 1.54) | 1.53 (1.00, 2.33) | |
| Urine output (ml/24 h) | 0.2991 | ||||
| < 1805.00 | 399 | 1.0 | 1.26 (0.79, 2.01) | 1.84 (1.21, 2.82) | |
| ≥ 1805.00 | 399 | 1.0 | 1.54 (0.87, 2.73) | 3.20 (1.86, 5.50) | |
HR hazard ratio, CI confidence interval, AF atrial fibrillation, CHF chronic heart failure, CDK chronic kidney disease, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, prior MI prior myocardial infarction, ACEI/ARBs angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, PTCA/PCI percutaneous transluminal coronary angioplasty/percutaneous coronary intervention, ALT alanine aminotransferase, AST aspartate aminotransferase, CK creatine kinase, CK-MB MB isoenzyme of creatine kinase, PT prothrombin time, RDW red cell distribution width, BUN blood urea nitrogen, WBC white blood cell, MBP mean blood pressure, ICU LOS length of ICU stay, SAPS II simplified acute physiology score II, SOFA sequential organ failure assessment score