Figure 4.

MT1 and radiotherapy (RT) combination relies on CD8⁺ T cells, and induces long-term antitumor memory.(A) Quantification of the bioluminescent signal from individual TC1/luc tumors was performed at different time points post-treatment in the different groups treated with or without anti-CD8 antibody (aCD8). (B) Kaplan-Meier mouse survival curves (For A-B, n=11–12 mice/group from two independent experiments). (C) Left panel shows images of the bioluminescent signal 10 days after TC1/Luc injection in 10 mice previously treated with RT and MT1 that underwent complete TC1/Luc tumor clearance and that were still tumor free 60 days after tumor grafting (Rechallenged), and in five treatment-naïve mice (Untreated). Right panel present the summary table of mice that developed or not tumors. For all panels: *p<0.05; **p<0.01; ***p<0.001 (log-rank test).