TABLE 5: TB treatment adopted at triage and during follow-up among DR-TB patients according to the intervention arm.
| Intervention Arm | ||||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Arm 1 | Arm 2 | ||||||
| MGIT | Xpert | OR* (95%CI) | P-value | MGIT | LPA | OR* (95%CI) | P-value | |
| N (%) | N (%) | N (%) | N (%) | |||||
| Empirical treatment | ||||||||
| Yes | 43 (97.7) | 9 (45.0) | 56 (98.2) | 27 (67.5) | 26.9 (3.35-216.9) | |||
| 1st line drug | 31 | 17 | 52.5 (6.0-460.08) | p<0.01 | 50 | 26 | p<0.001 | |
| 2nd line drug | 13 | 3 | 1.0 | 7 | 14 | 1.0 | ||
| No | 1 (2.3) | 11 (55.0) | 1 (1.8) | 13 (32.5) | ||||
| TB treatment adopted at triage | ||||||||
| Maintained the regimen prescribed earlier by health unit | 17 (38.6) | 8 (40.0) | 0.94 (0.32-2.78) | p=1.00 | 29 (50.9) | 14 (35.0) | 1.92 (0.83-4.41) | |
| Started new regimen | 27 (61.4) | 12 (60.0) | 1.0 | 28 (49.1) | 26 (65.0) | 1.0 | p=0.12 | |
| TB treatment that matches withreference standard DST(including those withempirical treatment) | ||||||||
| Yes | 35 (100) | 14 (82.4) | - | p=0.04 | 51 (100.0) | 29 (93.5) | - | p=0.14 |
| No | 0 (0.0) | 3 (17.6) | 0 (0.0) | 2 (6.5) | ||||
| SSM 2nd month | ||||||||
| Positive | 9 (27.3) | 3 (20.0) | 1.5 (0.34-6.58) | p=0.72 | 16 (43.2) | 11 (35.5) | 1.38 (0.52-3.7) | p=0.51 |
| Negative | 24 (72.7) | 12 (80.0) | 1,0 | 21 (56.8) | 20 (64.5) | 1.0 | ||
| Not reported | 11 | 5 | 20 | 9 | ||||
| SSM 6th month | ||||||||
| Positive | 6 (19.4) | 0 (0) | p=0.16 | 4 (14.8) | 10 (34.5) | 0.33 (0.08-1.22) | p=0.09 | |
| Negative | 25 (80.6) | 12 (100) | - | 23 (85.2) | 19 (65.5) | 1.0 | ||
| Not reported | 13 | 8 | 30 | 11 | ||||
| Culture 2nd month | ||||||||
| Positive | 22 (64.7) | 5 (35.7) | 3.3 (0.89-12.1) | p=0.06 | 20 (54.1) | 13 (50.0) | 1.17 (0.43-3.21) | p=0.75 |
| Negative | 12 (35.3) | 9 (64.3) | 1.0 | 17 (45.9) | 13 (50.0) | 1.0 | ||
| Not reported | 10 | 6 | 3 | 31 | ||||
| Culture 6th month | ||||||||
| Positive | 6 (29.7) | 1 (9.1) | 2.60 (0.27-24.6) | p=0.39 | 6 (17.0) | 6 (20.0) | 0.86 (0.24-3.01) | p=0.81 |
| Negative | 23 (79.3) | 10 (90.9) | 1.0 | 29 (83.0) | 25 (80.0) | 1.0 | ||
| Not reported | 15 | 9 | - | 22 | 9 | |||
| Any change in TB treatment after the triage | ||||||||
| Yes | 34 (77.3) | 14 (70.0) | 1.45 (0.44-4.78) | p=0.53 | 43 (75.4) | 25 (65.8) | 1.59 (0.64-3.93) | p=0.30 |
| No | 10 (22.7) | 6 (30.0) | 1.0 | 14 (24.6) | 13 (34.2) | 1.0 | ||
| Not reported | - | - | - | 2 | ||||
| Adverse reaction | ||||||||
| Yes | 10 (23.8) | 4 (22.2) | 1.09 (0.29-4.09) | p=1.00 | 5 (11.4) | 7 (18.9) | 0.54 (0.15-1.90) | p=0.36 |
| No | 32 (76.2) | 14 (77.8) | 1.0 | 39 (88.6) | 30 (81.1) | 1.0 | ||
| Not applicable | 2 | 2 | 13 | 3 | ||||
| Treatment outcome at6th month | ||||||||
| Favorable | 35 (79.5) | 17 (85.0) | 0.68 (0.16-2.86) | 43 (76.8) | 29 (76.3) | 1.02 (0.38-2.7) | p=0.95 | |
| Unfavorable | 9 (20.5) | 3 (15.0) | 1.0 | p=0.74 | 13 (23.2) | 9 (23.7) | 1.0 | |
| Lost of follow-up | 3 | 1 | 8 | 1 | ||||
| Failure | 6 | 1 | 3 | 7 | ||||
| Death | 0 | 1 | 2 | 1 | ||||
| Transferred | 1 | 2 | ||||||
Legend: SSM: sputum smear microscopy; OR: odds ratio; MGIT: BactecTMMGITTM 960 system; Xpert: Xpert®MTB/RIF; LPA: line probe assay.