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. Author manuscript; available in PMC: 2022 Mar 18.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2021 Jul 27;14(1):437–465. doi: 10.1146/annurev-anchem-091520-085936

Figure 6.

Figure 6.

Applications of microfluidic devices in mass spectrometry. (A) Microfluidic paper analytical device (PAD)-MS, which is developed by combination of immunoassay techniques and utilization of ionic probes (i), followed by subsequent MS analysis via touch paper spray ionization method once solvent is added (ii and iii). Adopted with permission from Reference 112. (B) Illustration of integrated multichannel microfluidic chip-MS which consist of a homemade manipulator, a hybrid capillary, a PDMS-glass microfluidic chip. Once cartridge droplet is generated, subsequent MS analysis is achieved via paper spray ionization with the aid of spraying solvent. Adopted with permission from Reference 114.