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. 2022 Mar 17;17(1):556–565. doi: 10.1515/med-2022-0429

Figure 4.

Figure 4

miR-22-5p regulates SSCs’ self-renewal by targeting EZH2. Human SSCs were co-transfected with miR-22-5p mimics and the EZH2 overexpression plasmid. (a and b) Cell proliferation was measured by EdU staining. (c and d) Cell apoptosis was analyzed by Annexin V/PI staining. (e and f) The expression of SSC markers (GDNF and DAZL) and apoptosis-related proteins (Caspase-3, Bax and Bcl-2) were detected by western blot. *p < 0.05, **p < 0.01 vs mimic NC + vector; #p < 0.05, ##p < 0.01 vs miR-22-5p mimic + vector.