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. 2022 Feb 1;219(3):e20210042. doi: 10.1084/jem.20210042

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© 2022 Dyck et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 8. — Weight loss restores T cell infiltration in endometrial cancer. (A and B) Patients with endometrial cancer (n = 9) were analyzed for weight loss (A) and cancer disease progression (B) after VSG. (C and D) Immune profile of tissue samples taken from a patient with endometrial cancer over the course of their treatment. The patient received VSG in April 2018, and samples were taken before and after VSG. (C) H&E (top panel) and IHC images of tumor tissue (T; blue) and IF (pink) stained for CD3, CD8, and PD-L1. Numbers in images represent the number of CD3⁺ or CD8⁺ T cells per mm² tumor or PD-L1 combined score. (D) CD3 and CD8 infiltration and PD-L1 scores over the course of weight loss. Significance was calculated using one-way ANOVA (A). ***, P < 0.001; ****, P < 0.0001.