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. 2022 Feb 25;219(3):e20211275. doi: 10.1084/jem.20211275

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© 2022 Ishida et al.

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Figure S2. — AQP4 deficiency markedly increases tau pathology stained with PHF-1 and MC1 in PS19 mice. (A) Representative images of 9-month-old PS19 × AQP4 (+/+), PS19 × AQP4 (+/−), and PS19 × AQP4 (−/−) mice stained with PHF-1. Scale bars, 1 mm. (B) Representative images of 9-month-old PS19 × AQP4 (+/+) and PS19 × AQP4 (−/−) mice stained with MC1. Scale bars, 300 μm. (C) Quantification of the percentage of area covered by MC1 staining in 9-month-old mice. Unpaired two-tailed t test; *, P < 0.05. n = 7/group.