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. 2022 Mar 18;8(11):eabl5547. doi: 10.1126/sciadv.abl5547

Fig. 3. Thalamic DBS induces remote brain activations.

Fig. 3.

(A) Effects of thalamic DBS induced on distant cortical areas. Cortical fMRI activation maps during low CT-DBS (top left), high CT-DBS (bottom left), low VL-DBS (top right), and high VL-DBS (bottom right). Individual results (monkey T), P < 0.05, family wise error (FWE)–corrected. (B) Effects of thalamic DBS on the blood oxygen level–dependent (BOLD) signal change (%) within the cortex. Red shading shows the stimulation period. High CT-DBS consistently activated a prefrontal parietal network. Only high CT-DBS activated both anterior and posterior cingulate cortices. (C) Effects of high CT-DBS on stationary FCs. Whole-brain average stationary intervoxel correlations before (blue), during high CT-DBS (green), and after high CT-DBS (yellow). (D) Average positive and negative z values before, during, and after high CT-DBS. In all plots, error bars represent 1 SEM. ACC, anterior cingulate cortex; area 9/46 [dorsolateral prefrontal cortex (PFCdl)]; area 8A [part of frontal eye field (FEF)]; area 6V [dorsolateral premotor cortex (PMCdl)]; area M1, primary motor cortex; PFG, parietal area PFG; VIP, intraparietal cortex (Pcip); PCC, posterior cingulate cortex; TPO, temporo-parieto-occipital–associated area in superior temporal sulcus.