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Model‐predicted and observed human (a) Cmax and (b) AUC0–inf from first‐in‐human study. The solid middle lines are the line of unity, while the upper and lower dashed lines represent two‐fold under‐ or overprediction. AUC0–inf, area under the plasma concentration–time curve extrapolated to infinity; Cmax, maximum concentration; IV, intravenous; PK, pharmacokinetic; SC, subcutaneous
