TABLE 1.

Parameters of the final exposure‐efficacy response model

Pharmacodynamic model	Estimate (% RSE)	Bootstrap estimate b (95% CI)
$\text{logit}\left({\mathrm{P}}_{\text{cured}}\right)={\text{BL}}_{\text{logit}\left({\mathrm{P}}_{\text{cured}}\right)}+\frac{{\mathrm{E}}_{\text{max}}\times {\text{AUC}}_{0‐24\mathrm{h}}}{\mathrm{E}50+{\text{AUC}}_{0‐24\mathrm{h}}}‐\text{INT}$ a
${\text{BL}}_{\text{logit}\left({\mathrm{P}}_{\text{cured}}\right)}$	−0.69 (50)	−0.70 (−1.51–0.05)
Emax	4.60 (7.5)	4.66 (3.95–5.49)
E50	79.2 (29)	77.8 (36.1–128.5)
INT a	1.42 (23)	1.47 (0.80–2.27)

Abbreviations: AUC_0–24h, area under the concentration time curve from zero to 24 hours; BL, baseline; BL_{logit(Pcured)} , Logit transformed baseline probability of being cured; CI, confidence interval; E50, AUC_0–24h where effect is half of E_max; E_max, maximum effect; INT, infection intensity factor (apply if infection intensity is moderate‐to‐high).

^a Include infection intensity factor only if infection intensity is moderate‐to‐high.

^b Based on n = 500 replicates.