TABLE 2.
Genotypes frequencies in the investigation cohort
| Gene | SNP | Genotype | N (%) | p value |
|---|---|---|---|---|
| ABCB1 | c.1199G>A | GG | 63 (90.0%) | 1 |
| GA | 2 (2.9%) | |||
| AA | 0 (0%) | |||
| Missing | 5 (7.1%) | |||
| c.3435C>T | CC | 14 (20.0%) | 0.619 | |
| CT | 30 (42.9%) | |||
| TT | 21 (30.0%) | |||
| Missing | 5 (7.1%) | |||
| ABCC1 | c.2012G>T | GG | 56 (80.0%) | 0.312 |
| GT | 8 (11.4%) | |||
| TT | 1 (1.4%) | |||
| Missing | 5 (7.1%) | |||
| CYP3A5 | g.6986A>G | *1/*1 | 0 (0%) | 1 |
| *1/*3 | 7 (10.0%) | |||
| *3/*3 | 58 (82.9%) | |||
| Missing | 5 (7.1%) | |||
| CYP3A4 | g.15389C>T | *1/*1 | 61 (87.1%) | 1 |
| *1/*22 | 4 (5.7%) | |||
| *22/*22 | 0 (0%) | |||
| Missing | 5 (7.1%) | |||
| SLCO1B1 | c.388A>G | AA | 25 (35.7%) | 0.799 |
| AG | 30 (42.9%) | |||
| GG | 10 (14.3%) | |||
| Missing | 5 (7.1%) | |||
| c.521T>C | TT | 44 (62.9%) | 0.109 | |
| TC | 16 (22.9%) | |||
| CC | 5 (7.1%) | |||
| Missing | 5 (7.1%) | |||
| SLCO1B3 | c.334T>G | TT | 46 (65.7%) | 0.661 |
| GT | 17 (24.3%) | |||
| GG | 2 (2.9%) | |||
| Missing | 5 (7.1%) | |||
| SLCO2B1 | c.935G>T | GG | 1 (1.4%) | 0.486 |
| GT | 11 (15.7%) | |||
| TT | 53 (75.7%) | |||
| Missing | 5 (7.1%) |
The p value is for Haldane’s exact test (*<0.05).
Abbreviation: SNP, single nucleotide polymorphism.