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PK data in hFcRn transgenic mice. Area under the curve (AUC), half-life (T1/2), and total clearance (CL) of 5A6-SG1095, 5A6CCS1-SG1095, and 5A6CCS1-SG1095ACT3 in human FcRn transgenic mice administered with IVIG after intravenous injection
| Antibody | Dosage (mg/kg) |
AUCINF (day*ug/mL) |
CL (mL/day/kg) |
T1/2 (day) |
Vss (mL/day) |
|---|---|---|---|---|---|
| 5A6CCS1-SG1095ACT3 | 2.0 | 564 | 3.57 | 16.7 | 83.4 |
| 5A6CCS1-SG1095 | 2.0 | 245 | 8.25 | 10.8 | 104 |
| 5A6-SG1095 | 2.0 | 136 | 15.2 | 8.24 | 138 |
