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. 2022 Mar 14;15:2979–2990. doi: 10.2147/IJGM.S346482

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© 2022 Liu et al.

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Analysis of the differentially expressed ferroptosis-related genes (DE-FRGs). (A) Overlapped DE-FRGs in Venn diagram; (B) protein-protein-interaction (PPI) network of 6 DE-FRGs. (C) principal component analysis of these DE-FRGs; (D) gene expression level of 6 DE-FRGs was compared in AS and control groups with paired t-test, respectively. Significance markers: ****P < 0.0001.

Abbreviations: PC1, principal component 1; PC2, principal component 2; CDKN1A, cyclin dependent kinase inhibitor 1A; IL-6, interleukin 6; NOX4, NADPH oxidase 4; VLDLR, very low density lipoprotein receptor; ANGPTL7, angiopoietin like 7; AKR1C3, aldo-keto reductase family 1 member C3.