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. Author manuscript; available in PMC: 2022 Mar 18.
Published in final edited form as: Nat Aging. 2021 Jan 14;1(1):47–59. doi: 10.1038/s43587-020-00013-3

Fig. 1 |. Fasting, nutrient signaling and longevity in yeast.

Fig. 1 |

Starvation conditions in yeast cause a major lifespan extension mediated in large part by the lack of amino acids and sugars. On one hand, amino-acid restriction causes the inactivation of TOR–Pkh–S6k signaling; on the other hand, low glucose levels promote reduced activity of the Ras–adenylate cyclase (Cyr1)–PKA pathway. Both the amino-acid and the sugar pathways converge on and inactivate the serine threonine kinase Rim15. This, in turn, contributes to the activation of stress-resistance transcription factors Gis1, which binds to post diauxic shift (PDS) motif, and Msn2 and Msn4, orthologs of mammalian early growth response protein 1 (EGR1)1,19, which bind to stress-responsive element (STRE) motif.