Table 3.
Effect of the aqueous Spirulina extract incubation on the maximal vasomotor response (Emax) and on the logarithm of effective concentration 50 (pEC50) of acetylcholine (ACh), sodium nitroprusside (SNP), CO releasing molecule (CORM), cromakalim (CK) and noradrenaline (NA) in aorta from aged rats.
|
E
max
|
pEC50 |
|||
|---|---|---|---|---|
| Control | Spirulina | Control | Siprulina | |
| ACh | 71.82 ± 5.47 | 73.36 ± 4.93 | –7.06 ± 0.11 | –8.16 ± 0.21** |
| SNP | 97.50 ± 1.67 | 108.0 ± 2.08** | –7.96 ± 0.16 | –9.11 ± 0.14** |
| CORM | 44.0 ± 8.8 | 56.25 ± 14 | –4.99 ± 0.13 | –5.23 ± 0.07 |
| CK | 93 ± 3.07 | 106.7 ± 3.98* | –7.05 ± 0.39 | –8.29 ± 0.53* |
| NA | 1407 ± 379 | 2403 ± 283* | –6.89 ± 0.20 | –6.76 ± 0.16 |
Values (mean ± SEM) are expressed as a percentage of relaxation (ACh, SNP, CORM and CK) and in mg (NA) for Emax and as log EC50 for pEC50. Statistical significances: *p < 0.05, **p < 0.001 compared to control condition (in the absence of the Spirulina extract).