Table 1.

In vitro cytotoxicity of the antibodies, MMAE and ADCs.

Cell lines	Test compound (IC50, nM)
	Herceptin	mil40	MMAE	mil40-12a	mil40-12b	mil40-12c
BT-474	2.2192	1.5406	0.2986	0.0937	0.1026	0.1038
NCI-N87	0.5447	0.3599	0.1611	0.0513	0.0536	0.0587
SK-BR-3	0.2425	0.2739	0.1164	0.0201	0.0258	0.0232
Sk-OV-3	>2703	2762.6134	0.6444	0.2151	0.2074	0.2372
MCF-7	>2703	3009.3732	0.4028	23.3137	26.4386	20.0725
MDA-MB-468	1233.4115	917.1025	0.1043	24.1351	11.5147	12.7128