Table 6.

Characteristics of echinocandins as medical preparations^{5,10,17,18,22,51,89,90}.

Active pharmaceutical ingredient	Physical form	Support substances	Reconstituting using	Storage	Dosage	Treated diseases
Caspofungin acetate	Lyophilised white powder, freely soluble in water (reconstitution required)	Sucrose, mannitol, acetic acid, NaOH	0.9% sodium chloride solution or sterile water	At temperatures less than or equal to 25 °C for 24 hours or at 2 to 8 °C for 48 hours	70 mg (saturation dose), then 50 mg daily (maintenance dose); 50 mg daily*	Fungal infections in patients with fever and neutropenia, candidemia, invasive aspergillosis (in patients resistant or intolerant to other therapies); oesophageal candidiasis, intra-abdominal abscesses, peritonitis, and pleural space infections
Micafungin sodium	Lyophilised powder, freely soluble in water (reconstitution required)	Lactose, citric acid, NaOH	0.9% sodium chloride solution or 5% dextrose	Stable for 24 hours at room temperature when protected from light	No saturating dose, 100 or 50 mg daily; No saturating dose, 150 mg daily*	Candidemia; oesophageal candidiasis, intra-abdominal abscesses, peritonitis, and pleural space infections
Anidulafungin	Lyophilised powder, insoluble in water (reconstitution required)	Fructose, mannitol, polysorbate 80, tartaric acid, NaOH or HCl	0.9% sodium chloride solution, 5% glucose solution, 20% dehydrated alcohol in water	In the refrigerator up to 24 hours	200 mg (saturating dose), then 100 mg daily (maintenance doses); 100 mg (saturation dose), then 50 mg daily (maintenance dose)*	Candidemia; oesophageal candidiasis, intra-abdominal abscesses, peritonitis, and pleural space infections
Rezafungin acetate	Lyophilised powder, freely soluble in water (reconstitution required)	Mannitol, polysorbate 80, histidine	0.9% sodium chloride solution or sterile water	Stable for over an year and shows minimal degradation	400 mg first week followed by 200 mg once weekly	Invasive candidiasis, aspergillosis and pneumocystis pneumonia

*Underlined special dosages are applied for oesophageal candidiasis.