Figure 7.

THC treatment reduces Snpp-prompted IP-10, IL-6, and nitrite production in P. a. LPS–stimulated BV2 microglial cells. BV2 microglial cells were pretreated with THC (40 μM) or HO-1 inhibitor Snpp (20 μM) for 1.5 h before being stimulated with P. aeruginosa LPS (0.1 μg/ml) for 24 h. The production of (a) IP-10, (b) IL-6, and (c) nitrite was determined using ELISA. The experimental quantitative data are presented in terms of mean ± SD (n = 3). Bars with the same letter represent no significant difference between the groups. Bars with different letters indicate a statistically significant (p < 0.05) difference between the groups.