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. 2022 Mar 11;2022:4564471. doi: 10.1155/2022/4564471

Figure 5.

Figure 5

Omav reduced the expression of proinflammatory genes and proteins after ICH. (a) Immunofluorescence staining for Iba-1 (green) and iNOS (red) in the ipsilateral basal ganglia region 3 days after ICH; the nuclei were stained with DAPI (blue); scale bar: 50 μm (n = 6). (b) Quantification of the ratio of microglia expressing iNOS. (c–e) qRT-PCR analysis of the expression of the mRNAs encoding iNOS, IL-1β, and TNF-α (n = 3). (f) Western blot showing iNOS levels in peripheral hematoma tissues from each group (n = 6). (g) Quantitative analysis of the iNOS band. (h–i) The concentrations of IL-1β and TNF-α in perihematoma 3 days after ICH were detected using ELISAs (n = 6). Data are presented as the means ± SEM. ∗P < 0.05 and ∗∗P < 0.01 compared with the control group; #P < 0.05 and ##P < 0.01 compared with the OxyHb group; †P < 0.05 and ††P < 0.01 compared with the OxyHb+Omav group.