Table 5.
Target information of G-Re in the treatment of IR in network pharmacology.
| No. | Gene symbol | Uniprot ID | Protein name |
|---|---|---|---|
| 1 | STAT3 | P40763 | Signal transducer and activator of transcription 3 |
| 2 | IL2 | P60568 | Interleukin-2 |
| 3 | AKT2 | P31751 | Serine/threonine-protein kinase AKT2 |
| 4 | ROCK1 | Q13464 | Rho-associated protein kinase 1 |
| 5 | AKT1 | P31749 | Serine/threonine-protein kinase AKT |
| 6 | S1PR1 | P21453 | Sphingosine 1-phosphate receptor Edg-1 |
| 7 | IGF1R | P08069 | Insulin-like growth factor I receptor |
| 8 | EGFR | P00533 | Epidermal growth factor receptor erbB1 |
| 9 | MMP1 | P03956 | Matrix metalloproteinase 1 |
| 10 | MAPK8 | P45983 | Mitogen-activated protein kinase 8 |
| 11 | MAPK9 | P45984 | Mitogen-activated protein kinase 9 |
| 12 | SYK | P43405 | Tyrosine-protein kinase SYK |
| 13 | GRB2 | P62993 | Growth factor receptor-bound protein 2 |
| 14 | MTOR | P42345 | Serine/threonine-protein kinase mTOR |
| 15 | DPP4 | P27487 | Dipeptidyl peptidase IV |
| 16 | SLC37A4 | O43826 | Glucose-6-phosphate translocase |
| 17 | LTB4R | Q15722 | Leukotriene B4 receptor 1 |
| 18 | PIK3CA | P42336 | PI3-kinase p110-alpha subunit |
| 19 | CSF1R | P07333 | Macrophage colony stimulating factor receptor |
| 20 | ADRB2 | P07550 | Adrenergic receptor beta |
| 21 | NTRK1 | P04629 | Nerve growth factor receptor Trk-A |
| 22 | NTRK2 | Q16620 | Neurotrophic tyrosine kinase receptor type 2 |
| 23 | ROCK2 | O75116 | Rho-associated protein kinase 2 |
| 24 | HDAC6 | Q9UBN7 | Histone deacetylase 6 |
| 25 | MMP9 | P14780 | Matrix metalloproteinase 9 |
| 26 | MMP2 | P08253 | Matrix metalloproteinase 2 |
| 27 | CDK2 | P24941 | Cyclin-dependent kinase 2 |
| 28 | SELL | P14151 | Leukocyte adhesion molecule-1 |
| 29 | SELP | P16109 | P-selectin |
| 30 | SRC | P12931 | Src tyrosine kinase |
| 31 | GSR | P00390 | Glutathione reductase |
| 32 | SOD2 | P04179 | Superoxide dismutase |
| 33 | PPP5C | P53041 | Serine/threonine-protein phosphatase 5 |
| 34 | PLA2G2A | P14555 | Phospholipase A2 |