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. 2022 Mar 11;2022:5436979. doi: 10.1155/2022/5436979

Table 5.

Target information of G-Re in the treatment of IR in network pharmacology.

No. Gene symbol Uniprot ID Protein name
1 STAT3 P40763 Signal transducer and activator of transcription 3
2 IL2 P60568 Interleukin-2
3 AKT2 P31751 Serine/threonine-protein kinase AKT2
4 ROCK1 Q13464 Rho-associated protein kinase 1
5 AKT1 P31749 Serine/threonine-protein kinase AKT
6 S1PR1 P21453 Sphingosine 1-phosphate receptor Edg-1
7 IGF1R P08069 Insulin-like growth factor I receptor
8 EGFR P00533 Epidermal growth factor receptor erbB1
9 MMP1 P03956 Matrix metalloproteinase 1
10 MAPK8 P45983 Mitogen-activated protein kinase 8
11 MAPK9 P45984 Mitogen-activated protein kinase 9
12 SYK P43405 Tyrosine-protein kinase SYK
13 GRB2 P62993 Growth factor receptor-bound protein 2
14 MTOR P42345 Serine/threonine-protein kinase mTOR
15 DPP4 P27487 Dipeptidyl peptidase IV
16 SLC37A4 O43826 Glucose-6-phosphate translocase
17 LTB4R Q15722 Leukotriene B4 receptor 1
18 PIK3CA P42336 PI3-kinase p110-alpha subunit
19 CSF1R P07333 Macrophage colony stimulating factor receptor
20 ADRB2 P07550 Adrenergic receptor beta
21 NTRK1 P04629 Nerve growth factor receptor Trk-A
22 NTRK2 Q16620 Neurotrophic tyrosine kinase receptor type 2
23 ROCK2 O75116 Rho-associated protein kinase 2
24 HDAC6 Q9UBN7 Histone deacetylase 6
25 MMP9 P14780 Matrix metalloproteinase 9
26 MMP2 P08253 Matrix metalloproteinase 2
27 CDK2 P24941 Cyclin-dependent kinase 2
28 SELL P14151 Leukocyte adhesion molecule-1
29 SELP P16109 P-selectin
30 SRC P12931 Src tyrosine kinase
31 GSR P00390 Glutathione reductase
32 SOD2 P04179 Superoxide dismutase
33 PPP5C P53041 Serine/threonine-protein phosphatase 5
34 PLA2G2A P14555 Phospholipase A2