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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Lancet Gastroenterol Hepatol. 2021 Oct 22;6(12):1002–1014. doi: 10.1016/S2468-1253(21)00312-5

Figure 1.

Figure 1.

Figure 1.

Figure 1.

Network of included studies with the available direct comparisons for (A) induction of clinical remission in biologic-naïve patients, (B) induction of clinical remission in biologic-exposed patients, and for (C) maintenance of remission in patients with moderate-severe Crohn’s Disease. The size of the nodes and the thickness of the edges are weighted according to the number of studies evaluating each treatment and direct comparison, respectively.