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. 2022 Feb 9;41(12):1809–1820. doi: 10.1038/s41388-022-02218-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A TIMP1 abundance in serum EVs from healthy donors (HD), CRC liver MET and CRC detected by ELISA (n = 20 per group). B TIMP1 abundance in the corresponding serum from healthy donors (HD), CRC liver MET and CRC detected by ELISA (n = 20 per group). C Receiver operating characteristic (ROC) curves showing superior stratification power of TIMP1^EV (AUC = 709) compared to total serum TIMP1 levels (AUC = 0.610). D Kaplan-Meier curve of overall survival of patients with high or low TIMP1^EV based on the estimated median TIMP1^EV value in the discovery cohort. E, F Kaplan-Meier curve of overall survival of patients with high or low TIMP1^EV in validation cohort I (E) and Validation cohort II (F) based on the cut-off value of the TIMP1^EV estimated from the discovery cohort. P values were calculated by one-way ANOVA test (A, B) and log-rank test (D, E, and F). Error bars depict mean ± SEM. *p < 0.05, ns not significant.