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. 2022 Feb 9;41(12):1821–1834. doi: 10.1038/s41388-022-02212-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — DDR1-overexpressing SK-Hep1 (A) and Hep3B (B) cells were stably transfected with scramble or shARF6 (shARF6#1 and shARF6#2) plasmids to generate control (vector+scramble), DDR1-overexpressing (DDR1 + scramble), and DDR1-overexpressing but ARF6-knockdown (DDR1 + shARF6#1 and DDR1 + shARF6#2) stable cells. A, B, E Trans-well migration and invasion assays, wound healing assays were performed in indicated cells. C Lung metastasis from nude mice injected with SK-Hep1 and HLF cells by tail veins from both groups killed at 8 weeks, was measured by bioluminescent imaging (BLI), representative images of lung tissue sections, and number of lung metastatic foci in both groups (n = 9). D Representative hematoxylin and eosin staining of lung tissue sections, and incidence of lung metastasis in both groups of BALB/c (nu/nu) mice (n = 9).