Table 3.
Association between patient characteristics and the formation of gallstones and/or sludge in the subset (n = 669)
| Univariable | Multivariable† | |||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Preoperative | ||||
| Age – years | 0.97 (0.96 to 0.99) | 0.006 | 0.98 (0.96 to 1.00) | 0.04 |
| Gender – female vs male | 1.14 (0.69 to 1.89) | 0.61 | - | |
| Weight at surgery – kg | 1.00 (0.99 to 1.01) | 0.60 | x* | |
| Body mass index at surgery – kg/m2 | 1.02 (0.97 to 1.06) | 0.49 | x* | |
| Hypertension – yes vs. no | 0.81 (0.53 to 1.23) | 0.32 | - | |
| Dyslipidemia – yes vs. no | 0.67 (0.42 to 1.08) | 0.10 | - | |
| Type 2 diabetes – yes vs. no | 1.19 (0.70 to 2.03) | 0.52 | 1.80 (0.97 to 3.34) | 0.06 |
| Pain syndrome – yes vs. no | 1.48 (0.77 to 2.84) | 0.24 | - | |
| Type of surgery – RYGB vs. sleeve gastrectomy | 0.80 (0.40 to 1.59) | 0.52 | - | |
| Statin use – yes, no (%) | 0.47 (0.24 to 0.90) | 0.02 | 0.42 (0.20 to 0.90) | 0.03 |
| Postoperative | ||||
| Intervention – UDCA vs. placebo | 0.46 (0.30 to 0.71) | < 0.001 | 0.47 (0.30 to 0.73) | < 0.001 |
| %TWL at 6 months – percent | 1.00 (0.97 to 1.04) | 0.85 | - | |
| %TWL at 12 months – percent | 1.00 (0.97 to 1.03) | 0.90 | x* | |
| %TWL at 24 months – percent | 1.01 (0.99 to 1.03) | 0.42 | x* | |
OR, odds ratio; CI, confidence interval; RYGB, Roux-en-Y gastric bypass; UDCA, ursodeoxycholic acid; TWL, total weight loss. *Variables not included in the multivariable model. †Variables excluded from the model following stepwise backward elimination: gender, hypertension, dyslipidemia, pain syndrome, type of surgery, and %TWL at 6 months