Table 2.
Comparative pharmacokinetics and toxicological analyses of PQd and PQPNN.
| PQd | PQPNN | |
|---|---|---|
| Pharmacokinetic analyses | ||
| GI absorption | High | Low |
| BBB permeant | No | No |
| P-gp substrate | Yes | No |
| CYP1A2 inhibitor | No | No |
| CYP2C19 inhibitor | No | No |
| CYP2C9 inhibitor | No | No |
| CYP2D6 inhibitor | No | No |
| CYP3A4 inhibitor | No | No |
| Toxicological analyses | ||
| Kv11.1 (hERG) inhibition | No | No |
| Carcinogenicity | No | No |
| Ames mutagenesis prediction | Negative | Negative |
Pharmacokinetics analyses were performed with SwissADME and the toxicological analyses were performed with Pred-hERG and AdmetSAR servers.