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Comparative information of Fmoc-l-Ala-l-Ala-COOMe dipeptide synthesis by the designed Fe3O4@SiO2/TABHA catalytic system, and solid-phase peptide synthesis method.
| Parameter | Fe3O4@SiO2/TABHA method | SPPS method |
|---|---|---|
| Process time (min) | 4 h | 4 h |
| Yield (%) | 90 | 94 |
| Purity (%) | > 98.0 | 94.4 |
| Complexity | Low | High |
| Additive materials | Triethylphosphite | TBTU, DIEA |
| Cost | Low | High |
| Reusability | Four cycles | No recycle |
