Table 1.

Factorial design matrix and experimental results obtained for the screening DoE.

Run	Factors			Responsesa
	HEMOXCell	Silicone-CaO2	O2 tension	ATP content (× 106 RLU)	ATP/LDH ratio (× 106 RLU/AU)	Insulin stimulation index
1	w/o	w/o	20% O2	13.52 ± 1.55	9.66 ± 4.42	3.1 ± 0.9
2	w/	w/o	20% O2	13.45 ± 2.64	7.78 ± 1.49	3.1 ± 0.1
3	w/o	w/	20% O2	9.09 ± 2.88	14.26 ± 1.45	3.1 ± 0.0
4	w/	w/	20% O2	13.43 ± 1.09	21.47 ± 6.16	4.5 ± 1.9
5	w/o	w/o	1% O2	6.11 ± 0.27	5.12 ± 1.72	1.7 ± 1.5
6	w/	w/o	1% O2	6.13 ± 0.59	4.94 ± 1.3	1.3 ± 0.8
7	w/o	w/	1% O2	13.98 ± 0.68	13.28 ± 8.81	2.2 ± 0.3
8	w/	w/	1% O2	15.41 ± 1.46	14.28 ± 4.99	2.5 ± 1.6

^aMean of three independent experiments.