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. 2022 Mar 18;12:4681. doi: 10.1038/s41598-022-07887-w

Table 3.

Multi-response optimization for the screening DoE.

Optimization Optimal level of factors Response values at the optimum
HEMOXCell Silicone-CaO2 O2 tension ATP content (× 106 RLU) ATP/LDH ratio (× 106 RLU/AU) Insulin stimulation index
Optimization in hypoxia w/ w/ Hypoxia 15.74 15.16 2.6