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. 2022 Mar 18;12:4681. doi: 10.1038/s41598-022-07887-w

Table 5.

Estimated effects of factors and interactions and their statistical significance in the optimization DoE (with silicone-CaO2).

Factors ATP content (× 106 RLU) ATP/LDH ratio (× 106 RLU/AU)
Estimated effect ± SD p-value* Estimated effect ± SD p-value*
A HEMOXCell concentration 4.9 ± 7.63 0.5238 − 1.37 ± 2.49 0.5859
B Islet seeding density 8.34 ± 7.64 0.0000 5.41 ± 2.72 0.0537
AA 2.89 ± 1.30 0.0307 − 2.14 ± 4.27 0.6193
BB − 3.49 ± 1.3 0.0098 − 7.65 ± 4.39 0.0893
AB interaction 1.64 ± 1.51 0.9142 6.22 ± 5.12 0.2310

*p-values are computed from the analysis of variance performed for each response (Supplementary Tables 4 and 5) and statistical significance at 5% are highlighted in bold.

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