TABLE 2.

Sequence differences for grlA genes^a

Strain	Sequence differences (% amino acids or nucleotides) with strain:
	S. epidermidis	S. warneri	S. capitis	S. haemolyticus	S. hominis	S. simulans	S. aureus	S. lugdunensis	S. saprophyticus	B. subtilis
S. epidermidis		0	1.22	3.75	1.22	2.45	3.71	6.29	10.34	23.98
S. warneri	13.0		1.22	3.75	1.22	2.45	3.71	6.29	10.34	23.98
S. capitis	14.5	12.1		2.48	2.45	3.71	4.99	7.62	10.34	23.98
S. haemolyticus	14.8	17.8	16.8		2.48	3.75	7.71	7.71	11.90	24.32
S. hominis	19.5	14.0	13.5	19.9		3.71	4.99	7.62	11.74	25.65
S. simulans	18.9	18.9	18.9	20.4	19.5		6.29	6.29	11.74	23.98
S. aureus	17.4	16.4	17.9	19.9	17.9	21.0		7.62	13.17	20.73
S. lugdunensis	16.9	17.4	15.4	19.9	17.9	20.5	19.5		16.11	22.34
S. saprophyticus	23.7	21.5	20.0	24.3	27.6	24.3	25.9	22.1		29.11
B. subtilis	41.3	39.0	40.3	36.4	41.7	43.8	42.4	41.7	44.6

^aDifferences are given as percentages of amino acids (above the diagonal) or nucleotides (below) over the 248 bp between primers tcn1 and tcn2 (Table 1), as determined by using the GCG Program “Distances” with the default parameters. All species are wild type and ciprofloxacin susceptible and are CoNS, aside from S. aureus and B. subtilis. The S. aureus sequence is that of Ferrero et al. (11), and the B. subtilis sequence is that of Kunst et al. (24) (GenBank Z99104). The S. lugdunensis sequence is that of the fluoroquinolone-susceptible isolate cn85. The other sequences were determined on the ATCC strains listed in Materials and Methods and as described there.